Los Angeles Chargers running back Gus Edwards was ruled out for Saturday’s road game against the New England Patriots with an ankle injury.

Fellow Chargers running back J.K. Dobbins is close to returning from a four-game absence because of a knee injury, as he was listed questionable to play.

Offensive lineman Trey Pipkins III (hip) and linebacker Denzel Perryman (groin) also have been ruled out for Saturday.

Edwards, 29, has gained 365 yards rushing this season with four touchdowns, including two in Los Angeles’ 34-27 victory over the Denver Broncos on Dec. 19.

Dobbins, 26, gained 766 yards with eight TDs in 11 games (nine starts) during his first season with the Chargers. Dobbins joined the Chargers in the offseason while coming off an Achilles tear with the Ravens last season.

The Chargers also have running backs Kimani Vidal and Hassan Haskins on the depth chart. Vidal, a rookie, has 131 yards in eight games this season, while Haskins has just 26 yards on 14 carries with a touchdown.

The Chargers (9-6) can clinch a playoff berth with a win or tie against the Patriots.